Antigen-Activated T Cells Induce IL-12p75 Production from Dendritic Cells in an IFN-γ-Independent Manner
نویسندگان
چکیده
منابع مشابه
Antigen-Independent IFN-γ Production by Human Naïve CD4+ T Cells Activated by IL-12 Plus IL-18
The role of T cells in innate immunity is not well defined. In this report, we show that a subset of human peripheral blood CD4(+) T cells responds to IL-12 plus IL-18, but not to IL-12 or IL-18 alone, by producing IFN-γ in the absence of any antigenic stimulation or cell proliferation. Intracellular staining reveals a small percentage of resting CD4(+) T cells (0.5 to 1.5%) capable of producin...
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متن کاملChapter IV
The addition of recombinant IL-12p75 (rIL-12p75) to naïve T cells promotes their differentiation toward a TH I-type cytokine patten by inducing IFN-y production. Therefore, it has been postulated that during the cognate interaction and formation of the immunological synapse between antigen-bearing DC and antigen-specific T cells, secretion of IFN-y and IL-12p75 would positively regulate each ot...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2010
ISSN: 0300-9475
DOI: 10.1111/j.1365-3083.2010.02467.x